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培美曲塞应在顺铂给药前 30 分钟给药。

在 恶性胸膜间皮瘤（MPM）关键试验和非鳞状非小细胞肺癌（NSCLC）一线治疗中，培美曲塞均先于顺铂给药。^1,2 最近针对晚期 NSCLC 的试验维持了相同的给药顺序。^3-5

上次审阅日期：2024年3月7日。

参考文献

1. Vogelzang NJ, Rusthoven JJ, Symanowski J, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003;21(14):2636-2644. https://doi.org/10.1200/JCO.2003.11.136

2. Scagliotti GV, Parikh P, von Pawel J, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol. 2008;26(21):3543-3551. https://doi.org/10.1200/JCO.2007.15.0375

3. Tachihara M, Dokuni R, Okuno K, et al. Phase II study of adjuvant chemotherapy with pemetrexed and cisplatin with a short hydration method for completely resected nonsquamous non-small cell lung cancer. Thorac Cancer. 2020;11(9):2536-2541. https://doi.org/10.1111/1759-7714.13567

4. Paz-Ares LG, de Marinis F, Dediu M, et al. PARAMOUNT: final overall survival results of the phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non–small-cell lung cancer. J Clin Oncol. 2013;31(23):2895-2902. http://dx.doi.org/10.1200/JCO.2012.47.1102

5. Gandhi L, Rodríguez-Abreu D, Gadgeel S, et al; KEYNOTE-189 Investigators. Pembrolizumab plus chemotherapy in metastatic non–small-cell lung cancer. N Engl J Med. 2018;378(22):2078-2092. https://doi.org/10.1056/nejmoa1801005